Young C Lin Selected Research

Zeranol

1/2013	Zeranol induces deleterious effects on the testes and the prostate gland of mature rats.
5/2011	Zeranol induces cell proliferation and protein disulfide isomerase expression in mammary gland of ACI rat.
2/2011	Serum derived from zeranol-implanted ACI rats promotes the growth of human breast cancer cells in vitro.
1/2011	Zeranol may increase the risk of leptin-induced neoplasia in human breast.
1/2011	Zeranol down-regulates p53 expression in primary cultured human breast cancer epithelial cells through epigenetic modification.
12/2010	Aromatase expression in leptin-pretreated human breast pre-adipocytes is enhanced by zeranol and suppressed by (-)-gossypol.
11/2010	Serum harvested from heifers one month post-zeranol implantation stimulates MCF-7 breast cancer cell growth.
9/2010	Zeranol enhances leptin-induced proliferation in primary cultured human breast cancer epithelial cells.
11/2009	Mitogenic activity of zeranol in human breast cancer cells is enhanced by leptin and suppressed by gossypol.
1/2007	Primary cultured human breast epithelial cells up-regulate protein disulfide isomerase in response to zeranol.

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Young C Lin Research Topics

Disease

28	Breast Neoplasms (Breast Cancer) 03/2013 - 01/2002
16	Neoplasms (Cancer) 03/2013 - 11/2002
7	Prostatic Neoplasms (Prostate Cancer) 07/2009 - 05/2002
6	Carcinogenesis 05/2011 - 01/2002
3	Lung Neoplasms (Lung Cancer) 01/2006 - 01/2002
2	Obesity 12/2010 - 11/2009
1	Atrophy 01/2013
1	Neoplasm Metastasis (Metastasis) 01/2004

Drug/Important Bio-Agent (IBA)

14	GossypolIBA 03/2013 - 01/2002
14	ZeranolIBA 01/2013 - 01/2002
11	Estrogens (Estrogen)FDA Link 04/2011 - 11/2002
8	Messenger RNA (mRNA)IBA 12/2011 - 01/2002
7	Cottonseed Oil (Cottonseed)IBA 12/2011 - 01/2004
6	Proteins (Proteins, Gene)FDA Link 06/2010 - 01/2004
5	Estradiol (Delestrogen)FDA LinkGeneric 01/2006 - 01/2002
4	LeptinIBA 01/2011 - 11/2009
4	Protein Tyrosine PhosphatasesIBA 06/2010 - 01/2002
3	Estrogen Receptor alphaIBA 08/2009 - 01/2006
3	Tamoxifen FDA LinkGeneric 08/2009 - 05/2006
3	Fibroblast Growth Factor 7 FDA Link 08/2009 - 05/2006
3	Conjugated Linoleic AcidsIBA 07/2008 - 11/2005
3	Hormones (Hormone)IBA 01/2007 - 05/2005
2	Liposomes (Liposome)IBA 12/2011 - 09/2008
2	Aromatase (CYP19)IBA 12/2010 - 05/2005
2	Cyclin D1IBA 07/2009 - 01/2004
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2007 - 05/2006
1	Paclitaxel (Taxol)FDA LinkGeneric 12/2011
1	Biomarkers (Surrogate Marker)IBA 05/2011
1	Endocrine DisruptorsIBA 04/2011
1	AdipokinesIBA 11/2010
1	Class 5 Receptor-Like Protein Tyrosine PhosphatasesIBA 06/2010
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 08/2009
1	Transforming Growth Factor beta (TGF-beta)IBA 07/2009
1	Fatty Acids (Saturated Fatty Acids)IBA 07/2008
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2007
1	Dextrans (Dextran)FDA Link 09/2006
1	Charcoal (Charbon)IBA 09/2006
1	Blood Proteins (Serum Proteins)IBA 09/2006
1	Bovine Serum AlbuminIBA 09/2006
1	Trypan Blue FDA Link 05/2006
1	Coloring Agents (Dyes)IBA 05/2006
1	Peptides (Polypeptides)IBA 05/2006
1	DNA (Deoxyribonucleic Acid)IBA 05/2006
1	CaspasesIBA 05/2006
1	Progesterone Receptors (Progesterone Receptor)IBA 05/2006
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 03/2006
1	Dinoprostone (PGE2)FDA Link 03/2006
1	Linoleic Acid (Linoleate)IBA 03/2006
1	Estrogen ReceptorsIBA 01/2006
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 11/2005
1	Piroxicam (Feldene)FDA LinkGeneric 05/2005
1	N- (2- cyclohexyloxy- 4- nitrophenyl)methanesulfonamideIBA 05/2005
1	1- ((4- methylsulfonyl)phenyl)- 3- trifluoromethyl- 5- (4- fluorophenyl)pyrazoleIBA 05/2005
1	Celecoxib (Celebrex)FDA Link 05/2005
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 05/2005
1	Enzyme Inhibitors (Inhibitors, Enzyme)IBA 05/2005
1	EnzymesIBA 05/2005
1	Ibuprofen (Motrin)FDA LinkGeneric 05/2005
1	Indomethacin (Indometacin)FDA LinkGeneric 05/2005
1	Niflumic AcidIBA 05/2005
1	nimesulide (Aulin)IBA 05/2005
1	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 05/2005
1	Insulin-Like Growth Factor I (IGF-1)IBA 03/2005
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 02/2004
1	Tyrosine (L-Tyrosine)FDA Link 02/2004
1	AgarIBA 02/2004
1	ThymidineIBA 01/2004
1	AndrogensIBA 01/2004
1	Transforming Growth Factor beta1 (TGF beta 1)IBA 01/2004

Therapy/Procedure

3	Mammaplasty (Breast Reconstruction) 01/2006 - 01/2002
2	Therapeutics 05/2006 - 05/2005
1	Drug Therapy (Chemotherapy) 01/2007